Which squadron has never operated in the U.S. Navy's Second Fleet area?

The North Africa Squadron's historical mission was primarily focused on suppressing the transatlantic slave trade and enforcing commerce laws along the African coast, particularly in regions such as West Africa. This squadron's operations were generally conducted far from the Atlantic waters that fall under the jurisdiction of the U.S. Navy's Second Fleet. The Second Fleet is responsible for naval operations in the North Atlantic and is often associated with forces operating out of United States bases and installations in the eastern U.S. and Canadian areas of responsibility.

Conversely, the Atlantic Squadron, Caribbean Squadron, and European Squadron operated in regions that would have included areas of the Second Fleet's purview at various points in their operational histories. The Atlantic Squadron, for instance, played a key role in actions during the early years of U.S. Navy operations in the Atlantic. The Caribbean Squadron was engaged in the preservation of U.S. interests in the Caribbean, while the European Squadron often operated in coordination with European navies, reinforcing their presence in the Atlantic as well.

Thus, identifying the North Africa Squadron as the correct choice highlights its distinct operational focus and geographical scope, distinguishing it from the other squadrons that were more involved in activities covered by the Second Fleet.